Amino Acid Clock(AmiAge Clock)

Biological age, an indicator encapsulates the intricate interplay of genetic, environmental, and lifestyle factors that steer our growth, development, and aging process, has emerged as an accurate signature of health status. Amino acids play a crucial role in numerous physiological processes, including protein synthesis, metabolism, and cellular signaling, all of which are directly involved in the growth, development, and aging process. we developed an Amino Acid Age (AmiAge) clock using 8 serum amino acids in several demographically diverse datasets (Atlas Project and UK Biobank, aged 1-89 years) and the random forest framework.

*Click the AmiAge clock button to perform AmiAge analysis.

Support

Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

The quickest way of reaching us is by contacting us directly on E-mail: chentianlu@sjtu.edu.cn or dingkeke@sjtu.edu.cn

We appreciate your questions and feedback.

References

[1]Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779.https://doi.org/10.1371/journal.pmed.1001779

[2]Argentieri MA, Xiao S, Bennett D, Winchester L, Nevado-Holgado AJ, Ghose U, et al. Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med. 2024;30(9):2450-60.https://doi.org/10.1038/s41591-024-03164-7